Influenza A vaccination associated with 6.3 times more aerosol shedding than non vaccinated

Posted by: Calilo | January 24, 2018

Influenza A vaccination associated with 6.3 times more aerosol shedding than non vaccinated

Natural immunity for the win.

Editors Note (Ralph Turchiano): I encourage you to review the full study as I shall link it below. I am only highlighting the two outcomes that require urgent further investigation due to the rapid mutagenicity of H3N2 .

Study Quote # 1 “In adjusted models, we observed 6.3 (95% CI 1.9–21.5) times more aerosol shedding among cases with vaccination in the current and previous season compared with having no vaccination in those two seasons.”

Study Quote #2 “ The association of current and prior year vaccination with increased shedding of influenza A might lead one to speculate that certain types of prior immunity promote lung inflammation, airway closure, and aerosol generation. This first observation of the phenomenon needs confirmation. If confirmed, this observation, together with recent literature suggesting reduced protection with annual vaccination, would have implications for influenza vaccination recommendations and policies.

Full Text Link: http://www.pnas.org/content/early/2018/01/17/1716561115.full